For me, it's not about whether he'll get enough rest afterwards, but rather what shape is he in to play this game.Mkhiky doesn't have to play for his national team, so I don't mind him starting at all. He will have time enough for rest afterwards.
If he's tired or not at 100% I don't think we should start him just because there is a 2 week break coming. I think we need to play our best 11, taking into account fitness/etc. The Bologna game was a good example that playing starting 11 before the break isn't neccessarily the best option if those players are coming off a match played 3 days prior.
This is a different scenario though as we actually rested quite a few starters - Lautaro, Dimarco, Barella, Dumfries all had little or no minutes in the last match. I do think De Vrij should start. Thuram looked very tired but Sanchez also just started and Arnautovic has not played in 1.5 months - who knows, maybe Inzaghi surprises us and starts him here.
Either way, we need to take this game seriously and hopefully a convincing win.