Absolutely terrible decision to put on Murillo. I don't see the point in that change for this game.
Just making that one change has a huge effect as it changes everyone's position in the defensive line, including the wing-backs. There was no need for it either. If you need to, shore up the midfield either with Gnoukouri or Felipe Melo.
From what I recall, he put on Vidic against Wolfsburg to switch to 3 at the back and we conceded right away. All this substitution does is confuse the team unless you know well how to play in it the way Juventus does. Mancini's logic seems to be: Need to defend? Bring on an extra defender. Need to score? Bring on an attacker. It's not always like that and he constantly ignores the midfield.