Been a while since I did one of these, and the market hasn't even opened, but let's do it:
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Bench: Handanovic, Cordaz, D'Ambrosio,
Milenkovic,
Vanheusden, Dimarco, Darmian,
Bellanova, Gagliardini,
Asllani,
Mkhitaryan,
Dybala, Dzeko, random Primavera forward.
I don't believe we'll succeed in preventing the Skriniar sale and therefore I think we'll opt to keep Dumfries. We're also too incompetent to sell De Vrij, so he'll stay and probably go on a free next year.
If this were to be the team, I imagine we would start with De Vrij at CB and Bremer RCB while Bremer and Milenkovic get settled in to the team's transitions. De Vrij would be phased out over the course of the season, with Bremer taking over in the middle and Milenkovic at RCB.
I think, despite the wingbacks looking very strong on paper, we'll struggle in those areas. Both are absolute trains and physical monsters, but both lack technical quality (see Perisic, Cancelo) and so unless they get the ball in space or run onto a through ball there'll be a lot of passing backwards/sideways. The work of Lukaku to open up space for Dumfries would be absolutely crucial in that case, as would Dybala finding Gosens during overloads/counters.
We'll actually have people who can play football on the bench in the midfield, so improvement all around there. I would love someone like Loftus-Cheek instead of Gagliardini but I think that's unlikely.
Up front is an upgrade of colossal proportions. Lautaro/Dzeko/Sanchez/Correa --> Lautaro/Lukaku/Dybala/Dzeko is ridiculous, with players who actually complement each other and can sub in for each other without ending up with poorly matched up pairs.
This would 100% be a Scudetto team, and I would be disappointed if we didn't complete a domestic double. QFs of the CL, depending on the draw. Would really rely on people like Bastoni, Barella, Brozovic, Lautaro, and Lukaku to step up in terms of leadership however, particularly with no Skriniar and no Handanovic (at least on the pitch).